Activated Clotting Time (ACT) for Monitoring of Low-Dose Heparin: Performance Characteristics in Healthy Adults and Critically Ill Patients
In heparin-spiked blood, ACT is sensitive to heparin at levels of ≥0.1 IU/ml heparin. In ICU-patients, ACT did not correlate with UFH dose or other established methods. Both systems were differently influenced by certain parameters.
Outcomes of Cardiac Surgery in Jehovah’s Witness Patients: A Review.
The use of a bloodless protocol for Jehovah’s Witnesses does not appear to significantly impact upon clinical outcomes when compared to non-Witness patients, and it has even been suggested that a bloodless approach could provide advantages to all patients undergoing cardiac surgery. Larger cohorts and research across multiple centres into the long term outcomes of these patients is required.
Prompt Prediction of Fibrinogen Concentration During Cardiopulmonary Bypass: A Pilot Study
Our results indicate a strong correlation between fibrinogen activation and serum fibrinogen concentration. The maximum amplitude of activator f can estimate low fibrinogen concentration faster than traditional methods; this method quickly provides important information for anesthesia and hemostatic management in cardiac surgery.
Exposure–Response Relationship of Tranexamic Acid in Cardiac Surgery: A Model-based Meta-analysis
In cardiopulmonary bypass surgery, low-dose tranexamic acid seems to be an appropriate regimen for reducing bleeding outcomes. This meta-analysis has to be interpreted with caution because the results are observational and dependent on the lack of bias of the predicted tranexamic acid exposures and the quality of the included studies.
Tranexamic Acid and Convulsive Seizures After Isolated Coronary Artery Bypass Surgery: The Role of Cardiopulmonary Bypass and Renal Function
Our data in patients undergoing isolated CABG indicate no significant effect on CS risk by use of CPB when TXA doses of up to ∼2 g are given. However, caution regarding TXA administration is necessary in patients with renal impairment.
Pitfalls of Commonly Used Anticoagulation Monitoring Techniques in Antiphospholipid Syndrome During Cardiopulmonary Bypass
Herein the authors report a case of a patient with APS undergoing PTE that highlights several limitations of the available coagulation monitoring strategies. The patient provided written consent for publication of the details of the case.
Incidental Detection of Factor XII Deficiency Following Coronary Artery Bypass Grafting
In conclusion, fXII deficiency is a very rare disorder that is manifested by elevated aPTT and ACT values. Timely diagnosis, adequate perioperative coagulation monitoring, and postoperative prophylaxis with LMWH will minimize the occurrence of complications.
Acute Normovolemic Hemodilution for A Patient with Secondary Polycythemia Undergoing Aortic Valve Replacement Due to Severe Aortic Stenosis – A Case Report
We estimate that patients with secondary polycythemia may benefit from acute normovolemic hemodilution to reduce their hematocrit levels while undergoing cardiac surgery using cardiopulmonary bypass. However, it is necessary to control the hematocrit level, since a significant decrease can cause side effects.
Anticoagulation Management in Severe Coronavirus Disease 2019 Patients on Extracorporeal Membrane Oxygenation
Hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients are common and possibly increase the propensity for thrombotic events and failure of the oxygenator. Currently, there is not enough evidence to support a more aggressive anticoagulation strategy.
Prothrombin Complex Concentrate vs. Fresh Frozen Plasma in Adult Patients Undergoing Heart Surgery – A Pilot Randomised Controlled Trial (PROPHESY Trial)
Haemostatic tests have provided useful insight into the haemostatic changes following prothrombin complex concentrate or fresh frozen plasma administration. A definitive trial is needed to ascertain the benefits and safety for each.
Blood Transfusion Threshold in Patients Receiving Extracorporeal Membrane Oxygenation Support for Cardiac and Respiratory Failure—A Systematic Review and Meta-Analysis
The present study did not resolve uncertainty as to transfusion management in ECMO, although several studies (most of them in VV ECMO) demonstrated that a restrictive threshold has acceptable outcomes in single-center cohorts.
A Last Resort When There is No Blood: Experiences and Perceptions of Intraoperative Autotransfusion Among Medical Doctors Deployed to Resource-Limited Settings
The participants found that simple IAT is under-utilised in resource-limited settings. Missed opportunities to use IAT were mainly associated with armed conflict settings and obstetrical emergencies.