How to forecast tomorrow’s transfusion: A focus on recipients’ profiles
Red blood cell (RBC) transfusion is a crucial medical intervention that plays a vital role in the care of surgical patients. However, due to the decreasing availability of blood donations and supplies, there is a pressing need for accurately predicting the likelihood of transfusion for surgical patients.
Prothrombin Complex Concentrate vs Plasma for Post-Cardiopulmonary Bypass Coagulopathy and Bleeding: A Randomized Clinical Trial
The results of this study suggest a similar overall safety and efficacy profile for PCCs compared with plasma in this clinical context, with fewer posttreatment intraoperative RBC transfusions, improved PT/INR correction, and higher likelihood of allogeneic transfusion avoidance in patients receiving PCCs.
Impact of Cardiopulmonary Bypass Duration on Efficacy of Fibrinogen Replacement with Cryoprecipitate Compared with Fibrinogen Concentrate: A Post Hoc Analysis of the Fibrinogen Replenishment in Surgery (FIBRES) Randomised Controlled Trial
The haemostatic efficacy of FC was non-inferior to cryoprecipitate irrespective of CPB duration in cardiac surgery.
Prolonged Blood Storage and Risk of Posttransfusion Acute Kidney Injury
In a population of patients without severely impaired baseline renal function receiving fewer than 10 erythrocyte units, duration of blood storage had no effect on the incidence of posttransfusion acute kidney injury.
A Comparative Analysis of Factors Influencing Haemoglobin Content in RBC Units
The marked variation of haemoglobin content in our study revealed that there is a need for standardizing RBC unit. Labelling of units with haemoglobin content and transfusion based on it will result in better patient care.
Restrictive Versus Liberal Transfusion in Patients with Diabetes Undergoing Cardiac Surgery: An Open-Label, Randomized, Blinded Outcome Evaluation Trial
The presence of diabetes did not modify the effect of a restrictive transfusion strategy on the primary composite outcome, but improved its efficacy on red cell transfusion. Restrictive transfusion triggers are safe and effective in patients with diabetes undergoing cardiac surgery.
Safety of Intra-Operative Blood Salvage During Liver Transplantation in Patients with Hepatocellular Carcinoma, A Propensity Score-Matched Survival Analysis
In conclusion, IBS during LT did not increase the risk for HCC recurrence. IBS is a safe procedure in HCC LT recipients to reduce the need for allogenic blood transfusion.
Recovery of Platelet-Rich Red Blood Cells and Acquisition of Convalescent Plasma With A Novel Gravity-Driven Blood Separation Device
The novel blood filter studied effectively separates whole blood into diluted plasma and platelet-rich RBCs. Moreover, the device effectively washed diluted whole blood, driving over 80% of proteins to the liquid component.
Retrograde Autologous Priming Method Reduces Plasma Free Hemoglobin Level in Aortic Surgery
In this study, in patients undergoing aortic surgery, a reduction in the increase of fHb was observed with the rRAP method which is a simple procedure that does not require high cost or advanced technology.
Efficacy and Safety of Aprotinin in Paediatric Cardiac Surgery: A Systematic Review and Meta-Analysis
This meta-analysis suggests that aprotinin is effective and well tolerated in paediatric cardiac surgery. Given the large heterogeneity of the results and the risk of selection bias in observational studies, large randomised controlled trials are warranted.
Antifibrinolytic Drugs for the Prevention of Bleeding in Pediatric Cardiac Surgery on Cardiopulmonary Bypass: A Systematic Review and Meta-analysis
The available data demonstrate efficacy for all 3 antifibrinolytic drugs. Therefore, the agent with the most favorable safety profile should be used. As sufficient data are lacking, large comparative trials are warranted to assess the relative safety and appropriate dosing regimens in pediatrics.
Use of Laboratory Testing for Prediction of Postoperative Bleeding Volume in Cardiovascular Surgery
These results suggest that several clinical and routine laboratory parameters of coagulation were individually associated with bleeding volume during cardiovascular surgery. Determining the patterns of coagulopathy may potentially help guide transfusion during cardiovascular surgery.