White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model
In our model, exposure to circulatory cell-free Hb, with or without concomitant hyperoxia, did not significantly alter brain white matter development.
Platelet Transfusion Practice and Related Outcomes in Pediatric Extracorporeal Membrane Oxygenation
Platelet transfusion was common in this multisite pediatric extracorporeal membrane oxygenation cohort. Platelet transfusion volume was associated with increased risk of mortality, bleeding, and thrombosis.
Serum Alpha 1-antitrypsin Predicts Severe Acute Kidney Injury After Cardiac Surgery
In summary, sA1AT is a valuable predictor of severe AKI development and prolonged ICU and hospital stays in patients after cardiac surgery.
Vasoplegic Syndrome Following Cardiothoracic Surgery—Review of Pathophysiology and Update of Treatment Options
Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance.
In Vivo Protamine Titration Using Activated Coagulation Time to Neutralize Heparin Anticoagulation in Cardiac Surgery: Proof of Concept
The aim of the present study was to determine the optimal protamine/heparin ratio to reverse anticoagulation using IVPT curves.
Novel Antiplatelet Agents in Cardiovascular Disease
Although their long journey from animal studies to randomized clinical trials and finally administration in daily clinical routine has just begun, some of the new agents may in the future become meaningful additions to the pharmacological armamentarium in cardiovascular disease.
Review and Update: Hematologic Malignancies and Adult Cardiac Surgery
This review will distinguish the important points of characterizing, understanding, and managing hematologic malignancies in the cardiac surgical patient.
Myocardial Protection: a Forgotten Modality
The goals of a cardiac surgical procedure are both technical excellence and complete protection of cardiac function.
Impact of Cerebral Perfusion on Outcomes of Aortic Surgery: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis
For patients without aortic dissection and who require more than 30 minutes of circulatory arrest, optimal cerebral protection strategies are deep hypothermia with either antegrade or retrograde cerebral perfusion and moderate hypothermia with antegrade cerebral perfusion.
Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery The FLASH Randomized Clinical Trial
Among patients at risk of postoperative kidney injury undergoing major abdominal surgery, use of HES for volume replacement therapy compared with 0.9% saline resulted in no significant difference in a composite outcome of death or major postoperative complications within 14 days after surgery.
The Association between Cytokines and 365-Day Readmission or Mortality in Adult Cardiac Surgery
Pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 may be postoperative markers of cardiac injury, and IL-6, specifically, shows promise in predicting readmission and mortality following cardiac surgery.
Low Tidal Volumes Are Associated With Slightly Improved Oxygenation in Patients Having Cardiac Surgery
Lower time-weighted average intraoperative tidal volumes were associated with a very modest improvement in postoperative oxygenation in patients having cardiac surgery.