Potential for Stem Cell Use in Congenital Heart Disease
This article reports on the evolving field of stem cell therapy and its impact on the management of cardiac pathology, in particular congenital heartdisease.
A Strong Regenerative Ability of Cardiac Stem Cells Derived from Neonatal Hearts
We hypothesized that isolated neonatal-derived cardiac stem cells (CSCs) may have a higher regenerative ability than adult-derived CSCs and might address the structural deficiencies of congenital heart disease.
Shovel-Ready’ Applications of Stem Cell Advances for Pediatric Heart Disease
This review will focus on two advances in basic science that are now translating into clinical trials.
Characterization and functionality of cardiac progenitor cells in congenital heart patients
Human cardiac progenitor cells (hCPCs) may promote myocardial regeneration in adult ischemic myocardium. The regenerative capacity of hCPCs in young patients with nonischemic congenital heart defects for potential use in congenital heart defect repair warrants exploration.
PHD2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium
We studied if and how Prolyl hydroxylase domain protein 2 silencing in human adipose-derived stem cells (ADSCs) enhances their cardioprotective effects after transplantation into infarcted hearts.
Combination Therapy of Human Adipose-Derived Stem Cells and Basic Fibroblast Growth Factor Hydrogel in Muscle Regeneration
In this study, we determined whether the combination therapy using human adipose-derived stem cells (h-ADSCs) and basic fibroblast growth factor (bFGF) incorporated into hydrogel could enhance muscle regeneration in a muscle laceration animal model.
Nanosecond Pulse Electric Field Activation of Platelet-Rich Plasma Reduces Myocardial Infarct Size and Improves Left Ventricular Mechanical Function in the Rabbit Heart
In the current study, we used the novel, nonchemical method of nanosecond pulsed electric fields (nsPEF) to investigate the efficiency of a protocol involving the in vivo treatment of the ischemic and reperfused heart and heart cells in culture with platelet-rich plasma (PRP).
Platelet Concentrates, from Whole Blood or Collected by Apheresis
The quality and characteristics of platelets during storage are affected by a number of factors, such as anticoagulant, centrifugation and processing after collection, and pre- or post storage pooling, but when comparing literature on the various methods, most differences balance out.
Autologous Fat Grafting: Use of Closed Syringe Microcannula System for Enhanced Autologous Structural Grafting
This article provides background for use of acquiring autologous adipose tissue as a tissue graft and source of adult progenitor cells for use in cosmetic plastic surgery.
Radiological Interventions for Soft Tissue Injuries in Sport
This article reviews the various pharmacological agents and bioactive substrates that are available, and discusses the current evidence base of their use in common sports injuries.
Dual Effect of Platelet Lysate on Human Articular Cartilage: A Maintenance of Chondrogenic Potential and a Transient Proinflammatory Activity Followed by an Inflammation Resolution
Our findings support the concept that the platelet products have a direct beneficial effect on articular chondrocytes and could drive in sequence a transient activation and the resolution of the inflammatory process, thus providing a rational for their use as therapeutic agents in cartilage inflammation and damage.
An Orthopedic Tissue Adhesive for Targeted Delivery of Intraoperative Biologics
One emerging therapeutic trend in orthopedics is the use of intraoperative biologics (IOB), such as bone marrow (BM) and platelet-rich plasma (PRP), to stimulate healing. Here, we introduce the application of the biomaterial chondroitin sulfate succinimidyl succinate (CS-NHS) to deliver IOB in a hydrogel adhesive.