Hyperoxia During Cardiopulmonary Bypass Does Not Decrease Cardiovascular Complications Following Cardiac Surgery: the CARDIOX Randomized Clinical Trial
Data on the benefit or or harmful effects of oxygen level on ischemic reperfusion injuries in cardiac surgery are insufficient.
Effectiveness of Magnesium in Preventing Shivering in Surgical Patients: A Systematic Review and Meta-analysis
Clinical trials regarding the antishivering effect of perioperative magnesium have produced inconsistent results.
Del Nido Cardioplegia is Safe and Effective Myocardial Protection in Adult Patients Undergoing Cardiac Surgery: A Single Center Experience
Del Nido cardioplegia gains increasing popularity among adult cardiac surgeons.
Analysis of the Critical Determinants of Renal Medullary Oxygenation
We previously developed a three-dimensional computational model of oxygen transport in the renal medulla.
Detection and decontamination of Mycobacterium Chimaera and Other Non-tuberculosis Mycobacteria in Heater–cooler Devices Used in Cardiopulmonary Bypass: a Manufacturer and National Guidelines Summary, and a Potential Resolution to the Problem Requiring Further Investigation
Since 2011, invasive infections due to Mycobacterium chimaera have been diagnosed in patients with previous cardiac surgery.
A Century of Heparin
The year 2018 was the centennial of the naming of heparin by Emmett Holt and William Howell and the 102nd anniversary of Jay McLean’s discovery of an anticoagulant heparphosphatide at Johns Hopkins Hospital in Baltimore.
BloodSurf 2017: News From the Blood-biomaterial Frontier
From stents and large-diameter vascular grafts, to mechanical heart valves and blood pumps, blood-contacting devices are enjoying significant clinical success owing to the application of systemic antiplatelet and anticoagulation therapies.
Nitric Oxide Attenuates the Inflammatory Effects of Air During Extracorporeal Circulation
Cardiopulmonary bypass causes a systemic inflammatory response reaction that may contribute to postoperative complications. One cause relates to the air/blood interface from the extracorporeal circuit. The modulatory effects of blending nitric oxide (NO) gas into the ventilation/sweep gas of the membrane lung was studied in a porcine model of air-induced inflammation in which NO gas was added and compared with controls with or without an air/blood interface.
Autologous Platelet-Rich Plasmapheresis in Cardiovascular Surgery: A Narrative Review
Perioperative coagulopathy and bleeding are common complications in cardiovascular surgery with cardiopulmonary bypass and result in an increased rate of allogeneic blood transfusion. Both bleeding and transfusion can increase postoperative mortality and morbidity.
Red Blood Cell Dysfunction: a New Player in Cardiovascular Disease
The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon dioxide to the lungs. However, emerging evidence suggests an important role of the RBC beyond being just a passive carrier of the respiratory gases.
Dexmedetomidine Extraction by the Extracorporeal Membrane Oxygenation Circuit: Results From an in Vitro Study
Dexmedetomidine is a sedative administered to minimize distress and decrease the risk of life threatening complications in children supported with extracorporeal membrane oxygenation. The extracorporeal membrane oxygenation circuit can extract drug and decrease drug exposure, placing the patient at risk of therapeutic failure.
Enhanced Sternal Healing Through Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel
The aim of this study was to evaluate the effectiveness of the controlled release of PRP from biodegradable gelatin hydrogel for promoting healing in a rabbit ischemic sternal model.