Awake Off-pump Coronary Bypass Allows Speedy Recovery, Less Pain
Patients undergoing off-pump coronary artery bypass surgery while awake recover faster and report less postoperative pain than patients undergoing the same procedure […]
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The Effects of Normoxic Versus Hyperoxic Cardiopulmonary Bypass on Oxidative Stress and Inflammatory Response in Cyanotic Pediatric Patients Undergoing Open Cardiac Surgery: A Randomized Controlled Trial
This study investigates the effects of controlled reoxygenation cardiopulmonary bypass on oxidative stress, inflammatory response, and organ function in children undergoing repair of cyanotic congenital heart defects.
Toll-like Receptor 9 and the Inflammatory Response to Surgical Trauma and Cardiopulmonary Bypass
CPB, surgical trauma and ischemic perfusion injury trigger the release of circulating mtDNA that activates TLR-9, in turn stimulating a release of IL-6. Therefore, TLR-9 antagonists may attenuate this response and may provide a future therapeutic target whereby the systemic inflammatory response to cardiac surgery may be manipulated to improve clinical outcomes.