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Thrombocytosis and Neutrophilia Associated with Oxygenator Failure and Protamine Reaction after Cardiopulmonary Bypass: A Case Report and Literature Review
The patient subsequently suffered a severe protamine reaction that was successfully managed. A review of the literature of similar patients and the relevant cellular and biochemical mechanisms in this setting are presented, with potential therapeutic approaches to prevent such complications noted.
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Significant Reduction in Blood Loss in Patients Undergoing Minimal Extracorporeal Circulation
Recently a new concept, the mini-extracorporeal circulation, was introduced to minimize the side effects of extracorporeal circulation.
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Degradation of the Endothelial Glycocalyx Contributes to Metabolic Acidosis in Children Following Cardiopulmonary Bypass Surgery
Our data show that metabolic acidosis (increased strong ion gap) is associated with plasma concentration of heparan sulfate, a negatively charged glycosaminoglycan cleaved from the endothelial glycocalyx during cardiopulmonary bypass. In addition, cleavage of heparan sulfate was associated with renal dysfunction, capillary leak, and global markers of cardiovascular dysfunction. These data highlight the importance of designing translational therapies to protect the glycocalyx in cardiopulmonary bypass.
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