Effect of Intra-arterial Nimodipine on Cerebral Oxygen Saturation and Systemic Hemodynamic Indices in Patients With Cerebral Vasospasm: A Prospective Cohort Study
IaN for aSAH-related cerebral vasospasm did not improve rScO2 but was associated with significant systemic hemodynamic effects, including a decrease in MBP and TPRI. These hemodynamic changes might offset any potential effects of IaN to improve rScO2.
Platelet Function Analysed by ROTEM Platelet in Cardiac Surgery after Cardiopulmonary Bypass and Platelet Transfusion
ROTEM platelet with thrombin activation, TRAP‐tem, improved significantly, indicating that platelet transfusion may reverse cardiopulmonary bypass‐induced platelet dysfunction.
Cell-Cycle Arrest Biomarkers Usefulness for Cardiac Surgery-Related Acute Kidney Injury in Neonates and Infants
These findings question the usefulness of (TIMP-1) × (IGFBP-7) for the prediction of cardiac surgery-related acute kidney injury in neonates and infants when measured within 3 hours of cardiopulmonary bypass.
Increased Circulating Levels of Neutrophil Extracellular Traps During Cardiopulmonary Bypass
Circulating NETs measurements increases during cardiac surgery with postsurgical levels proportional to CPB duration. The clinical significance of NETs production during cardiac surgery should be further investigated.
The Relationship Between Neurocognitive Decline and the Heart‐Lung Machine
Further research, comparing on‐pump and off‐pump cohorts and involving intensive screening of preoperative cognitive decline, is indicated to elucidate the true neurocognitive consequences of the heart‐lung machine.
Sourcing Personal Protective Equipment During the COVID-19 Pandemic
An increase in PPE supply in response to this new demand will require a large increase in PPE manufacturing, a process that will take time many health care systems do not have, given the rapid increase in ill COVID-19 patients.
Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)
Myocardial injury is significantly associated with fatal outcome of COVID-19, while the prognosis of patients with underlying CVD but without myocardial injury is relatively favorable.
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status.
Outcome Impact of Different Tranexamic Acid Regimens in Cardiac Surgery with Cardiopulmonary Bypass (OPTIMAL): Rationale, Design, and Study Protocol of a Multicenter Randomized Controlled Trial
The study is designed to identify a TxA dose with maximal efficacy and minimal complications. We hypothesize that the high dose has superior efficacy and noninferior safety to the low dose.
Update on Extracorporeal Carbon Dioxide Removal: a Comprehensive Review on Principles, Indications, Efficiency, and Complications
Extracorporeal carbon dioxide removal means the removal of carbon dioxide from the blood across a gas exchange membrane without substantially improving oxygenation.
Large-Vessel Occlusion Stroke after Cardiothoracic Surgery: Expanding Time Windows Offer New Salvage Opportunities
LVO complicates a small proportion of patients after CTS and may be more likely with prolonged aortic crossclamp and cardiac bypass times.
Are We Close to Bioengineering a Human-Sized, Functional Heart?
The model ventricles can be evaluated with the same assays used in animal models and in clinical settings.