A Mock Circulation Loop to Test Extracorporeal CO2 Elimination Setups
We demonstrate a simple and cost effective, yet powerful, “in-vitro” ECCO2R model that can be used as an alternative to animal experiments for many research scenarios.
Urinary Neprilysin For Early Detection of Acute Kidney Injury After Cardiac Surgery: A Prospective Observational Study
Urinary neprilysin has potential as a biomarker for the early detection of AKI after cardiac surgery and has comparable discriminatory power to recently studied AKI biomarkers.
Predicting Survival After Extracorporeal Membrane Oxygenation by Using Machine Learning
This proof of concept study demonstrates the potential for machine learning models to augment clinical decision making for patients undergoing VA-ECMO. Further development with multi-institutional data is warranted.
Changing the Terminology from Kidney Replacement Therapy to Kidney Support Therapy
In this review, we discuss the use of various modes of kidney replacement therapy in treating renal and non‐renal complications to illustrate why kidney support therapy is a more appropriate terminology than renal replacement therapy.
Hemochromatosis Alters the Sensitivity of Red Blood Cells to Mechanical Stress
Given that blood products are commonly exposed to high‐shear environments (eg, during high‐volume transfusion), venesections from asymptomatic and untreated individuals with HH appear suboptimal for the development of therapeutic RBCs.
Feasibility of Venovenous Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation
Our results suggest that venovenous ECMO can be safely administered without continuous systemic anticoagulation therapy. This approach may be associated with reduced bleeding diathesis and need for blood transfusions.
Microplegia vs 4:1 Blood Cardioplegia: Effectiveness and Cost Savings in Complex Cardiac Operations
Our simplified microplegia technique offers several advantages over Buckberg cardioplegia without compromising myocardial protection or safety in complex, multicomponent operations with extended aortic clamp times.
Sustained Total All-Region (STAR) Perfusion for Norwood Reconstruction With Complex Intracardiac Repair
Here, we introduce a novel technique for sustained total all-region perfusion of the heart, upper body, and lower body throughout the Norwood operation.
Physiology of Extracorporeal Gas Exchange
Artificial lungs are mechanical devices in which blood is exposed to oxygen through a gas permeable membrane. Like the normal lung, the amount of gas exchange is controlled by the geometry of the device, the blood flow and composition, and the ventilating gas flow and composition.
Switch from Minimally Invasive Biventricular Mechanical Support to Cardiopulmonary Bypass During Heart Transplant
With this cardiopulmonary bypass configuration, orthotopic heart transplantation was routinely performed and, at the end of the procedure, the 2 cannulas were uneventfully removed.
Relationship of Intraoperative Perfusion Parameters to The Need for Immediate Extracorporeal Support Following Heart Transplantation
We note that DO2 < 300-AOC was significantly associated with the need for postoperative ECMO following heart transplant. Further study will clarify whether potential DO2 differences in patients who require post-OHT ECMO reflect vasoplegia, or a more causative relationship which might be leveraged to improve outcomes.