Automated Technique Accurately Measures Platelet Counts in “Platelet Gel” Products
A special blood concentrate known as platelet-rich plasma (PRP) can promote healing in a wide range of medical and surgical situations, but research has been limited by the lack of a universally accepted approach to measuring the platelet concentrations contained in PRP.
Freeze-Dried Platelet-Rich Plasma Shows Beneficial Healing Properties in Chronic Wounds
Fresh platelet concentrates are used in many centers to treat recalcitrant wounds. To extend the therapeutic shelf-life of platelets, we analyzed the wound-healing effects of fresh-frozen and freeze-dried (FD) platelet-rich plasma (PRP) using a diabetic mouse model.
An Experience With Cardiopulmonary Bypass in HIV-Infected Patients
Having noted the good clinical status of some HIV patients who were referred for but refused surgery, we undertook surgery with the aim of determining outcome, risk-to-benefit ratio and, if possible, the effect of surgery with cardiopulmonary bypass (CPB) on the progression of their HIV disease.
Myocardial Protection in the Failing Heart: I. Effect of Cardioplegia and the Beating State Under Simulated Left Ventricular Restoration
Heart failure was induced by cardiac pacing to evaluate myocardial flow distribution of the open ventricle during delivery of either cardioplegia or in the beating state during simulated left ventricular restoration.
Aprotinin Improves Cerebral Protection: Evidence From a Survival Porcine Model
The goal of the study was to test the hypothesis that aprotinin could reduce cerebral injury after low-flow cardiopulmonary bypass and deep hypothermic circulatory arrest.
Differences in Platelet Growth Factor Release and Leucocyte Kinetics During Autologous Platelet Gel Formation
Three commercial systems for whole blood separation were compared to obtain the buffy coat composed of platelet-rich plasma (BC-PRP) and leucocytes .
The Impact of Tissue Factor Pathway Inhibitor on Coagulation Kinetics Determined by Thrombelastography
Thrombelastography (TEG) is often used to monitor hemostasis in the perioperative period, and TFPI could potentially affect the diagnostic interpretation of TEG-based data, given its inhibition of both common and TF coagulation pathways. Thus, in this study we characterized the effect of TFPI on coagulation kinetics via TEG.
FDA Advisory Committee Strongly Endorses Use of Trasylol® in CABG Surgery Patients
Bayer was glad to participate in today’s advisory committee meeting held by the Cardiovascular and Renal Drugs Division of the U.S. Food and Drug Administration (FDA). This session provided an open forum in which to discuss the complex scientific issues surrounding the risk/benefit profile of Trasylol® (aprotinin injection) in detail.
Platelet Gel Sealant Use in Rhytidectomy
Quantitative assessments of postoperative drain fluid outputs were compared in subjects who did and did not receive platelet gel treatment.
Notice on Upcoming FDA Advisory Committee Meeting to Discuss Clinical Data for Aprotinin
Notice on Upcoming FDA Advisory Committee Meeting to Discuss Clinical Data for Aprotinin
Frontal Sinus Obliteration Using Tibial Bone Graft and Platelet-Rich Plasma for the Treatment of Chronic Osteomyelitis
Obliteration of the frontal sinus with tibial bone graft and PRP after sinus cleaning and curettage can be a good alternative in the treatment of chronic frontal sinus osteomielitis.
Platelet-Rich Plasma/Osteoblasts Complex Induces Bone Formation Via Osteoblastic Differentiation Following Subcutaneous Transplantation
The present study was undertaken to develop a clinical alternative to autologous bone, by investigating the application of PRP in combination with osteoblastic cells and evaluating its effects after transplantation.