Blood Management Newsletter February 2011
This month’s newsletter will focus on cerebral oximetry, which is slightly off topic but very much related to blood management. Cerebral oximetry, more precisely termed "Near-infrared spectroscopy" (NIRS), is a technique that can be used as a noninvasive and continuous monitor of the balance between cerebral oxygen delivery and consumption.
Protamine v1
Protamine A polycationic protein derived from salmon milt, possess strong alkalinity because of an amino acid composition consisting of 67% arginine. […]
Cryoprecipitate v1.0
Cryoprecipitate Cryoprecipitate contains 2 or more times the concentration of fibrinogen contained in plasma as well as increased levels of factor V […]
Protamine Reaction v1
I. DESCRIPTION: Following cardiopulmonary bypass with heparin anticoagulation, protamine sulfate is used to neutralize the effects of heparin and reverse anticoagulation. Currently […]
HIT
Heparin Induced Thrombocytopenia I. DESCRIPTION: Heparin induced thrombocytopenia (HIT) and heparin induced thrombocytopenia thrombosis syndrome (HITTS) are immune mediated complications of heparin […]
Cold Agglutinins v.1
I. BACKGROUND: Hypothermic cardiopulmonary bypass with the use of cold blood cardioplegia carries with it the risk of red cell agglutination caused […]
AT3 Deficiency v.1
Antithrombin III (AT III) is a plasma glycoprotein with a molecular weight of 58,000 daltons. AT III deficiency may be noticed when […]
Serotonin
Serotonin Serotonin functions as a neurotransmitter, is synthesized in the gastrointestinal mucosa, and is stored primarily in platelets and the endothelium of […]
Right Ventricular Function v. 1
Right Ventricular Function Patients with right coronary artery disease may be susceptible to right ventricular ischemia and infarction when right ventricular distension […]
Myocardial Oxygen Demand
Myocardial Oxygen Demand The heart extracts more oxygen than other tissues while at rest (50-70%). The heart’s normal compensation for increased […]
Myocardial Ischemia v.1
Myocardial Ischemia Prevention and treatment of perioperative myocardial ischemia is a primary consideration. Two consistent factors associated with the pathogenesis of myocardial […]