Update on Clinical Trials for the Prevention of Acute Kidney Injury in Patients Undergoing Cardiac Surgery
Effective therapeutic agents for the prevention and treatment of acute kidney injury (AKI) after cardiac surgery remain elusive despite the tremendous advances in surgical techniques, technology, and understanding of disease processes. Recent developments and their effect on the incidence of AKI after cardiac surgery are discussed.
Relevance of the Surgical Care Improvement Project on Glycemic Control in Patients Undergoing Cardiac Surgery Who Receive Continuous Insulin Infusions
This study was undertaken to (1) determine the incidence of SCIP outliers in patients receiving a continuous insulin infusion (CII) targeted to maintain perioperative serum glucose levels less than 180 mg/dL after cardiac surgery, (2) identify the profile of patients who are SCIP outliers, (3) determine whether SCIP outliers have increased morbidity and mortality, and (4) identify more relevant benchmarks for glycemic control in patients having cardiac surgery.
Preoperative Statin Therapy in Cardiac Surgery is More Effective in Patients Who Display Preoperative Activation of the Inflammatory System
We sought to determine whether preoperative statin treatment is more effective in reducing, after cardiac surgery with cardiopulmonary bypass, systemic inflammatory response and myocardial damage markers in patients who have elevated preoperative interleukin-6 levels than in patients who have normal preoperative interleukin-6 levels. The study involved a prospective cohort of 164 patients who underwent coronary and valvular surgery with cardiopulmonary bypass.
N-3 Polyunsaturated Fatty Acids to Prevent Atrial Fibrillation: Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Electronic searches were conducted in Web of Science, Medline, Biological Abstracts, Journal Citation Reports, and the Cochrane Central Register of Controlled Trials databases. In addition, data from the recently completed FORωARD and OPERA trials were included. We included randomized controlled trials comparing treatment with n-3 PUFAs versus control to (1) prevent recurrent AF in patients who underwent reversion of AF or (2) prevent incident postoperative AF after cardiac surgery.
Effect of an Investigational Vaccine for Preventing Staphylococcus Aureus Infections after Cardiothoracic Surgery: A Randomized Trial
This study evaluates the efficacy and safety of preoperative vaccination in preventing serious postoperative S. aureus infection in patients undergoing cardiothoracic surgery.
Cardiac Surgery in Patients with a Porcelain Aorta in the Era of Transcatheter Valve Implantation
The aim of the study was to evaluate operative and long-term results in patients with a porcelain aorta who underwent conventional cardiac surgery using current surgical and perfusion techniques.
Gaseous Micro-Emboli Activity during Cardiopulmonary Bypass in Adults: Pulsatile Flow versus Nonpulsatile Flow
We aimed to determine whether pulsatile CPB augments production and delivery of GME and evaluate the role of different events in GME activity during either type of perfusion.
Interventions for Preventing Post-Operative Atrial Fibrillation in Patients Undergoing Heart Surgery
We conducted an update to a 2004 Cochrane systematic review and meta-analysis of the literature to gain a better understanding of the effectiveness of these interventions.