Pilot Alternating Treatment Design Study of the Splanchnic Metabolic Effects of Two Mean Arterial Pressure Targets during Cardiopulmonary Bypass
The arterial pressure target for optimal splanchnic function during cardiopulmonary bypass (CPB) is uncertain.
Antifibrinolytics in Cardiac Surgery
Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended.
Management of Massive Bleeding in 2013: Seven Questions and Answers
The management of massive bleeding has improved, thanks to high-quality blood components and new transfusion strategies. However, it remains controversial and, despite a huge body of literature, randomised control trials are still lacking.
Immediate Effects of Individualized Heparin and Protamine Management on Hemostatic Activation and Platelet Function in Adult Patients Undergoing Cardiac Surgery with Tranexamic Acid Antifibrinolytic Therapy
This randomized prospective study was initiated to clarify whether individualized heparin and protamine dosing has immediate effects on hemostatic activation and platelet function in adult cardiac surgery.
Assessment and Management of Massive Bleeding: Coagulation Assessment, Pharmacologic Strategies, and Transfusion Management
This review details the current knowledge in massive hemorrhage with regard to the pathophysiology and laboratory assessment of the coagulation disturbance, the role of plasma and platelet transfusion, the role of pharmaceutical strategies, and the clinical value of having a massive transfusion protocol.
Low Hemorrhage-Related Mortality in Trauma Patients in a Level I Trauma Center Employing Transfusion Packages and Early Thromboelastography-Directed Hemostatic Resuscitation with Plasma and Platelets
This was a prospective study of adult trauma patients admitted to a Level I trauma center. Demography, Injury Severity Score (ISS), transfusion therapy, and mortality were registered. Hemostatic resuscitation was based on a massive transfusion protocolencompassing transfusion packages and thromboelastography (TEG)-guided therapy.
Platelet Concentrates, from Whole Blood or Collected by Apheresis
The quality and characteristics of platelets during storage are affected by a number of factors, such as anticoagulant, centrifugation and processing after collection, and pre- or post storage pooling, but when comparing literature on the various methods, most differences balance out.