Monitoring of Perfusion Quality and Prediction of Donor Heart Function During Ex-Vivo Machine Perfusion by Myocardial Microcirculation versus Surrogate Parameters
The combination of mLDP and Lac (r2 = 0.876, p = 0.005) showed best results. mLDP seems to be superior to Lac to show perfusion disorders and predict DCD-heart contractility.
Multi-institutional Analysis of 100 Consecutive Patients with COVID-19 and Severe Pulmonary Compromise Treated with Extracorporeal Membrane Oxygenation: Outcomes and Trends Over Time
Extracorporeal membrane oxygenation may facilitate salvage and survival of selected critically ill patients with COVID-19. Survivors tend to be younger. Substantial variation exists in the drug treatment of COVID-19, but ECMO offers a reasonable rescue strategy.
The Effects of the Combined Argatroban/Nitric Oxide-Releasing Polymer on Platelet Microparticle-Induced Thrombogenicity in Coated Extracorporeal Circuits
These results indicate that PMPs may be an important measure of platelet activation during ECC. Platelet-derived microparticles may provide a simplified way to measure platelet function during clinical ECC.
I-PASS Handover System: A Decade of Evidence Demands Action
Thus, consistent with all previous studies, I-PASS was implemented successfully and handover quality improved. However, is the lack of association of I-PASS implementation with clinical outcomes and adverse events in this study a concern? To answer this question, it is necessary to review the origins of I-PASS more than a decade ago and its continually expanding evidence base.
SARS-CoV-2 Leakage From the Gas Outlet Port During Extracorporeal Membrane Oxygenation for COVID-19
In conclusion, SARS-CoV-2 could leak to the gas outlet port of the ECMO circuit through silicone-coated polypropylene membranes during ECMO support of critically ill COVID-19 patients.
Influence of Administration of Mesenchymal Stromal Cell on Pediatric Oxygenator Performance and Inflammatory Response
The administration of mesenchymal stromal cells does not interfere with oxygenator function. Allogeneic mesenchymal stromal cells show no immunogenicity, and increase plasma IL-6 level during ex vivo circulation. Further investigation is necessary to determine the effect of mesenchymal stromal cell delivery through CPB during pediatric cardiac surgery.
Microcirculatory Effects of Landiolol: A Double-Blind, Randomised, Controlled Study after Cardiac Surgery
The aim of this prospective randomised, controlled, double-blind study conducted in patients undergoing cardiac surgery was to assess the microcirculatory effects of landiolol given at a moderate dose to prevent POAF. We tested the hypothesis that landiolol could limit cardiopulmonary-bypass-induced microcirculatory abnormalities.
Cardiac Surgery Simulation – Part II: Cannulation
Whereas a trainee has the opportunity to cannulate for cardiopulmonary bypass only once during a case, the trainee can utilize this simulation model to easily and faithfully practice each step hundreds of times to improve his or her technical skills and to be more prepared for the next case. We believe that practicing in this way can enhance intraoperative learning, performance, and confidence.
Diabetic Pathophysiology Enhances Inflammation during Extracorporeal Membrane Oxygenation in a Rat Model
These data demonstrate that diabetes enhances proinflammatory cytokine release, renal damage, and pulmonary edema during ECMO in an animal model.
Frequency Domain Analysis and Clinical Outcomes of Pulsatile and Non-Pulsatile Blood Flow Energy During Cardiopulmonary Bypass
PP provided more energy than NP. The proportion of low frequency energy in the pulsatile or nonpulsatile flow is significantly reduced. The low-frequency energy is significantly attenuated during conduction to peripheral tissues in nonpulsatile flow. The surplus pulsatile energy influences the secretion of endothelial and inflammatory factors, and demonstrate better cerebral and kidney protective effect at the biological marker level.
Altered Fibrinolysis during and after Surgery
Major surgery induces hemostatic changes related to surgical stress, tissue destruction, and inflammatory reactions. These changes involve a shift of volume from extravascular space to intravascular and interstitial spaces, a “physiologic” hemodilution of coagulation proteins, and an increase of plasmatic fibrinogen concentration and platelets.
Albumin in Adult Cardiac Surgery: A Narrative Review
In cardiac surgical patients, albumin is widely utilized despite a lack of high- quality evidence supporting its efficacy or safety. A well-designed randomized controlled trial is needed to clarify the role of albumin in cardiac surgical patients.