Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research
It is our hope that the present document will encourage and stimulate future prospective studies and randomized trials to study the safety, efficacy, and optimal use of these agents for prevention or management of thrombosis in COVID-19.
Charting a Safe and Expeditious Course Back to Elective Cardiac Surgery During the COVID-19 Pandemic
What has become clear amidst the flux and uncertainty of the pandemic is that we must find a way to remain available to our patients by charting a safe and expeditious path toward resumption of elective cardiac surgery.
Towards Integrative Neuromonitoring of the Surgical Newborn – A Systematic Review
Neuromonitoring with the techniques currently used will neither help our understanding of the altered neonatal pathophysiology, nor enable early detection of deviation from the norm. The modalities lack specificity and are not related to clinical (long-term) outcome or prognosis. Accordingly, we were unable to draw up a monitoring guideline.
Engineering Blood Outgrowth Endothelial Cells to Optimize Endothelial Nitric Oxide Synthase and Extracellular Matrix Production for Coating of Blood Contacting Surfaces
Taken together, our findings demonstrate that cell-ECM interactions are fundamental to the regulation of eNOS in BOECs and suggest that disruption of key intracellular pathways (such as ROCK) may be necessary to enhance functional activity of an endothelialized surface.
Volatile Anesthesia Versus Total Intravenous Anesthesia During Cardiopulmonary Bypass: A Narrative Review on the Technical Challenges and Considerations
With no demonstrable benefit of volatile anesthetics over TIVA for CABG, this narrative review focuses on the technical challenges and considerations regarding the administration of volatile anesthesia versus TIVA during CPB.
Review and Reflections about Pulsatile Ventricular Assist Devices from History to Future: Concerning Safety and Low Haemolysis — Still Needed
Volume displacement pumps can produce high blood pressure, so they are indispensable for clinical use today and in the future. In this work, nearly all pulsatile blood pumps used in clinical life are described.
Starting Elective Cardiac Surgery After 3 pm Does Not Impact Patient Morbidity, Mortality, or Hospital Costs
We report no differences in perioperative outcomes, operative mortality, length of stay, or total hospital cost for elective cases that start after 3 pm. This may be attributable to the resources available at a large quaternary center regardless of time of day.
Validation of the ‘Paediatric Extracorporeal Membrane Oxygenation Prediction’ Model in a UK Extracorporeal Membrane Oxygenation Centre
This small single-centre study with a small number of events was unable to validate the paediatric extracorporeal membrane oxygenation prediction-model of risk-adjustment. Although this remains the most promising of all the available models, further validation in larger data sets and/or refinement may be required before widespread use.
Fixed and Dilated Pupils, Not a Contraindication for Extracorporeal Support: a Case Series
The patients described demonstrate that fixed and dilated pupils are not a contraindication for extracorporeal support in select patients.
Thromboelastographic Results and Hypercoagulability Syndrome in Patients With Coronavirus Disease 2019 Who Are Critically Ill
Our findings suggest that alterations of diagnostic and prophylactic treatment guidelines may be critical for the successful treatment of coagulopathies associated with COVID-19.
Mortality and Pulmonary Complications in Patients Undergoing Surgery with Perioperative SARS-CoV-2 Infection: an International Cohort Study
Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery.
Managing Teamwork in the Face of Pandemic: Evidence-based Tips
We hope the evidence-based tips we provided about teamwork under stress can be used by healthcare providers, team leaders and management to take constructive actions both during and in the early aftermath of the COVID-19 pandemic.