Therapeutic Potential of Fibrinogen Γ-Chain Peptide-Coated, ADP-Encapsulated Liposomes as A Haemostatic Adjuvant for Post-Cardiopulmonary Bypass Coagulopathy
These findings suggest that H12-ADP-liposomes could help effectively and safely consolidate platelet haemostasis in post-CPB coagulopathy and may have potential for reducing bleeding complications after cardiovascular surgery with CPB.
Multiple Electrode Aggregometry After Cardiopulmonary Bypass to Assess Platelet (Dys)-Function and Transfusion Threshold: A Concordance Study
The application of new Multiplate analyzer technologies, like the ADP test, have the potential to reduce platelet transfusion rates in cardiac surgery patients compared with the use of platelet counts alone; this point-of-care test may constitute an important strategy to help spare the use of allogeneic blood products. Additional studies are needed to confirm this trend and establish the best cutoff values to apply.
Simulation-Based Training of Critical Events During Cardiopulmonary Bypass: Importance of A Critical Events Checklist
Evaluation of critical events during simulated cardiopulmonary bypass shows that the scenario is realistic and relevant for clinical practice. Integrating a critical events checklist improves the probability of correct decision-making and shortens the correct decision time.
Intravenous Iron Therapy for Patients with Preoperative Iron Deficiency or Anaemia Undergoing Cardiac Surgery Reduces Blood Transfusions: A Systematic Review and Meta-Analysis
This meta-analysis suggests that IV iron improves postoperative morbidity in adult cardiac surgery patients with preoperative anaemia or iron deficiency. A large, rigorous, placebo-controlled, double-blinded, multicentre trial is needed to clarify the role of IV iron in this patient population.
Therapeutic Plasma Exchange: A potential Management Strategy for Critically Ill COVID-19 Patients
Herein, we briefly discuss some of the various approaches currently being investigated for the treatment of SARS-CoV-2 with a focus on potential benefits of TPE for selected critically ill patients.
Effects of Cardiac Surgery and Salvaged Blood Transfusion on Coagulation Function Assessed by Thromboelastometry
Salvaged blood transfusion of more than 18.5% whole blood volume may impair coagulation function particularly in patients with lower FIBTEM-MCF before and after cardiac surgery.
p-Values and Their Unintended Consequences
We provide a suggested course of action, for both journal editors and readers, to address this issue.
Comparison of Postoperative Cognitive Decline in Patients Undergoing Conventional Vs Miniaturized Cardiopulmonary Bypass: A Randomized, Controlled Trial
This study shows that the MCPB was not superior to CCPB with cell salvage and biocompatible tubing with regard to the neurocognitive outcomes measured by the RBANS.
Evaluation of Arterial Stiffness in Cardiac Surgical Patients Using Applanation Tonometry
Cardiac surgery was associated with an improvement in arterial stiffness, A-V coupling, and myocardial contractility as assessed using applanation tonometry. The results suggest, however, a transient imbalance between myocardial oxygen supply and demand in the immediate postoperative period.
Development of A Real-Time Blood Damage Monitoring Device for Cardiopulmonary Bypass System Using Near-Infrared Spectroscopy
The results demonstrate the clinical potential of a real-time, low-cost, and reliable blood damage monitoring device to improve the safety of CPB operation.
The Long-Term Impact of Peripheral Cannulation for Redo Cardiac Surgery
This is the first study reporting the long‐term impact of peripheral cannulation for redo cardiac surgery after excluding patients with operative mortality. These data suggest that central cannulation may to be the preferred approach to redo cardiac surgery whenever safe and possible.
Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass
In children after cardiopulmonary bypass, lactates are not correlated with higher oxygen extraction, but are correlated with hyperglycemia, at both 4 and 12 h after PICU admission. Future research is warranted to better define this relationship.