World's Largest Resource for Cardiovascular Perfusion
Cardiac surgery continues to be associated with significant adverse cerebral outcomes, ranging from stroke to cognitive decline.
Bleeding after cardiac surgery requiring surgical reexploration and blood component transfusion is associated with increased morbidity and mortality. Although prothrombin complex concentrate (PCC) has been used satisfactorily in bleeding disorders, studies on its efficacy and safety after cardiopulmonary bypass are limited.
Protamine is an FDA-approved drug for use in neutralizing the effect of unfractionated heparin.[1][2] It is most commonly used to neutralize heparin-induced anticoagulation […]