Having physiological correct flow waveforms is a key feature for experimental studies of blood flow, especially in the process of developing and testing a new medical device such as stent, mechanical heart valve or any implantable medical device that involves circulation of blood through the device. It is also a critical part of a perfusion system for cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) procedures. This study investigated the feasibility of a novel roller pump for use in experimental flow phantoms. Flow rates of carotid flow profile measured directly with ultrasonic flow meter matched well with reference flow rates programmed into the machine with similarity index of 0.97 and measured vs programmed flow rates at specific time‐points of Peak Systolic Velocity (PSV): 0.894 vs 0.880, End Systolic Velocity (ESV): 0.333 vs 0.319 and Peak Diastolic Velocity (PDV): 0.514 vs 0.520 L/min. Flow rates derived from video analysis of the pump motion for carotid, suprarenal and infrarenal flows also matched well with references with similarity indices of 0.99, 0.99, and 0.96 respectively. Measured flow rates (mean/standard deviation) at PSV, ESV, and PDV time‐points for carotid: 0.883/0.016 vs 0.880, 0.342/0.007 vs 0.319, and 0.485/0.009 vs 0.520; suprarenal: 3.497/0.014 vs 3.500, 0.004/0.003 vs 0 and 1.656/0.073 vs 1.453; infrarenal: 4.179/0.024 vs 4.250, ‐1.147/0.015 vs ‐1.213 and 0.339/0.017 vs 0.391 L/min respectively. The novel roller pump is suitable for benchtop testing of physiological flow.
You may also like
Tranexamic Acid and Convulsive Seizures After Off-pump Coronary Artery Bypass Surgery: the Role of Renal Insufficiency
There is evidence that, in adult cardiac surgical patients undergoing on-pump procedures, tranexamic acid (TXA) dose-dependently increases the risk of convulsive seizure (CS).
Cell Salvage of Cardiotomy Suction Blood Improves the Balance between Pro- and Anti-Inflammatory Cytokines after Cardiac Surgery
Cell salvage reduces the absolute levels of both pro- and anti-inflammatory cytokines in cardiotomy suction blood and improves the balance in the systemic circulation after surgery.