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Perfusion NewswireBlood ManagementAnticoagulation in Pediatric Extracorporeal Life Support—Time for a More Direct Approach?

Anticoagulation in Pediatric Extracorporeal Life Support—Time for a More Direct Approach?

Blood Management, Perfusion Zone, Tiny Perfusion Letter

Unfractionated heparin (UFH) is the most commonly used anticoagulant used in extracorporeal life support (ECLS), but there is a subset of patients in whom this may not be effective or feasible (heparin resistance, significant thrombosis on UFH, heparin-induced thrombocytopenia). UFH exerts its principal anticoagulation affect by activating antithrombin; the UFH–anti-thrombin complex than inactivates thrombin, activated factor X, and other clothing factors. The indirect action of UFH is problematic because of the need for antithrombin. Additional difficulties with UF each include significant in vivo intrapatient and interpatient variability as well as achieving clinical efficacy with a reliable in vitro anticoagulation test.

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Perfusion Zone, Tiny Perfusion Letter

Education in Evidence-Based Health Care: Never A Greater Need

The pandemic has highlighted the importance of health science and research that is efficiently produced, evaluated and acted on. Hand in hand with this comes the ability to ask, find, appraise and apply evidence to support effective decisions. These abilities are essential skills—skills that need to be taught. Where there is a need to be taught, there is a need for people to teach. The final article in the series aims to aid EBHC educators in this mission. Through collaboration and consensus, our peers come together to provide aspiring EBHC teachers a resource of their go-to articles in support of effective and inspirational teaching and education.

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