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A Phase III, Double-blind, Placebo-controlled, Multicenter Study on the Efficacy of Recombinant Human Antithrombin in Heparin-resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass
Treatment with 75 U/kg rhAT is effective in restoring heparin responsiveness and promoting therapeutic anticoagulation in the majority of heparin-resistant patients. Treating heparin-resistant patients with rhAT may decrease the requirement for heparin and fresh frozen plasma.
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Is There a Suitable Method of Anticoagulation in Pregnant Patients with Mechanical Prosthetic Heart Valves?
A best evidence topic was written according to a structured protocol in order to identify the mode of anticoagulation that has the best safety profile for both the mother and the foetus in pregnant patients with mechanical prosthetic heart valves.
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Persistent Cognitive Deficits and Neuroinflammation In A Rat Model of Cardiopulmonary Bypass
By using an established rat model of CPB that does not display neuronal loss, we examined behavioral and structural effects of CPB at 6 months postsurgery. Persistent deficits in performance on a complex behavioral task and sustained activation of macrophages/microglia were observed with no evidence of neuronal loss.
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