World's Largest Resource for Cardiovascular Perfusion

Perfusion Newswirei-Pump Quick ReferenceQuick Reference: Protamine Reaction

Quick Reference: Protamine Reaction

Consider the possibility of protamine reaction in patients allergic to fish, previous protamine exposure, diabetics on NPH insulin and men who have had vasectomies.
High risk patients can be treated with antihistamines and steroids prior to protamine administration.  Consider having the surgeon administer protamine into the left atrium or directly into the aorta.
  1. Stop protamine administration
  2. Use 100% FiO2
  3. Stop inhalational anesthetics
  4. Start  volume expanders
Drugs to Consider:
  • Calcium chloride, catecholamines, antihistamines, aminophylline and corticosteroids
Be prepared to give heparin and go back on CPB if no response to pharmacologic interventions.

Leave a Reply

#1 largest online community of Perfusionists

Join Our
Online Community

Get your swag kit by becoming a member or updating profile.
Swag will be sent to U.S. mailing addresses only.
©2024 Perfusion. All Rights Reserved. Privacy Policy | Your Privacy Choices